Yengo Lab Publications

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Publications (in reverse chronological order)

  1. Within-family effect of ancestry on complex traits in a Mexican population

  2. Why pharmacogenomic biomarkers for chemotherapy-induced peripheral neuropathy fail: a systematic review of genetic associations, replication, and clinical translation

  3. Empirical evaluation of analytic validity of polygenic scores

  4. Pitfalls in estimating and interpreting the contribution of ultra-rare genetic variants to the heritability of complex traits

  5. Genetics of skeletal proportions across two different populations

  6. Distinct genetic profiles influence body mass index between infancy and adolescence

  7. Family-GWAS reveals effects of environment and mating on genetic associations

  8. Estimation and mapping of the missing heritability of human phenotypes

  9. Polygenic prediction of body mass index and obesity through the life course and across ancestries

  10. The contribution of gametic phase disequilibrium to the heritability of complex traits

  11. One Health Approach to the Computational Design of a Lipoprotein-Based Multi-Epitope Vaccine Against Human and Livestock Tuberculosis

  12. Genetic architecture reconciles linkage and association studies of complex traits

  13. Genome-wide fine-mapping improves identification of causal variants

  14. Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank

  15. Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries

  16. Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

  17. The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits

  18. Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

  19. Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D

  20. Identification and analysis of individuals who deviate from their genetically-predicted phenotype

  21. Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores

  22. Direct and INdirect effects analysis of Genetic lOci (DINGO): A software package to increase the power of locus discovery in GWAS meta-analyses of perinatal phenotypes and traits influenced by indirect genetic effects

  23. Genetics of skeletal proportions in two different populations

  24. Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci

  25. Mate choice through a genomic lens

  26. The effect of the scale of grant scoring on ranking accuracy

  27. Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose

  28. 15 years of GWAS discovery: Realizing the promise

  29. Genomics and phenomics of body mass index reveals a complex disease network

  30. Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study

  31. A saturated map of common genetic variants associated with human height

  32. Genetic footprints of assortative mating in the Japanese population

  33. Genetic and modifiable risk factors combine multiplicatively in common disease

  34. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

  35. Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

  36. Constrained human genes under scrutiny

  37. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

  38. Assortative mating biases marker-based heritability estimators

  39. Polygenic burden could explain high rates of affective disorders in a community with restricted founder population

  40. Discovery and implications of polygenicity of common diseases

  41. Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization

  42. Genomic partitioning of inbreeding depression in humans

  43. The trans-ancestral genomic architecture of glycemic traits

  44. Corrigendum to: Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness

  45. Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

  46. Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes

  47. Quantifying genetic heterogeneity between continental populations for human height and body mass index

  48. Widespread signatures of natural selection across human complex traits and functional genomic categories

  49. Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals

  50. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

  51. Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization

  52. Pathogenic variants in actionable MODY genes are associated with type 2 diabetes

  53. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

  54. Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

  55. Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock

  56. Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

  57. Risk in Relatives, Heritability, SNP-Based Heritability, and Genetic Correlations in Psychiatric Disorders: A Review

  58. A unified framework for association and prediction from vertex-wise grey-matter structure

  59. Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness

  60. No Evidence for Social Genetic Effects or Genetic Similarity Among Friends Beyond that Due to Population Stratification: A Reappraisal of Domingue et al (2018)

  61. Improved polygenic prediction by Bayesian multiple regression on summary statistics

  62. Genetic correlates of social stratification in Great Britain

  63. Extreme inbreeding in a European ancestry sample from the contemporary UK population

  64. Assortative Mating in Autism Spectrum Disorder: Toward an Evidence Base From DNA Data, but Not There Yet

  65. Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

  66. Genome-wide association study of medication-use and associated disease in the UK Biobank

  67. Imprint of assortative mating on the human genome

  68. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

  69. ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers

  70. Assortative mating on complex traits revisited: Double first cousins and the X-chromosome

  71. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

  72. Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

  73. Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

  74. Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

  75. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

  76. Misestimation of heritability and prediction accuracy of male-pattern baldness

  77. Association Between Population Density and Genetic Risk for Schizophrenia

  78. Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

  79. Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

  80. Signatures of negative selection in the genetic architecture of human complex traits

  81. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

  82. Reply to Kardos et al.: Estimation of inbreeding depression from SNP data

  83. Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

  84. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

  85. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

  86. Detection and quantification of inbreeding depression for complex traits from SNP data

  87. Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

  88. Early metabolic markers identify potential targets for the prevention of type 2 diabetes

  89. An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

  90. Genome-wide physical activity interactions in adiposity – A meta-analysis of 200,452 adults

  91. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

  92. Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

  93. KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

  94. Genome-wide analysis identifies 12 loci influencing human reproductive behavior

  95. Detection of human adaptation during the past 2000 years

  96. Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling

  97. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

  98. Associations Between Type 2 Diabetes-Related Genetic Scores and Metabolic Traits, in Obese and Normal-Weight Youths

  99. Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

  100. Genomic insights into the origin of farming in the ancient Near East

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