Yengo Lab Publications

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Publications (in reverse chronological order)

  1. Distinct genetic profiles influence body mass index between infancy and adolescence

  2. Family-GWAS reveals effects of environment and mating on genetic associations

  3. Estimation and mapping of the missing heritability of human phenotypes

  4. Polygenic prediction of body mass index and obesity through the life course and across ancestries

  5. The contribution of gametic phase disequilibrium to the heritability of complex traits

  6. One Health Approach to the Computational Design of a Lipoprotein-Based Multi-Epitope Vaccine Against Human and Livestock Tuberculosis

  7. Genetic architecture reconciles linkage and association studies of complex traits

  8. Genome-wide fine-mapping improves identification of causal variants

  9. Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank

  10. Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries

  11. Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

  12. The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits

  13. Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

  14. Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D

  15. Identification and analysis of individuals who deviate from their genetically-predicted phenotype

  16. Boosting the power of genome-wide association studies within and across ancestries by using polygenic scores

  17. Direct and INdirect effects analysis of Genetic lOci (DINGO): A software package to increase the power of locus discovery in GWAS meta-analyses of perinatal phenotypes and traits influenced by indirect genetic effects

  18. Genetics of skeletal proportions in two different populations

  19. Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci

  20. Mate choice through a genomic lens

  21. The effect of the scale of grant scoring on ranking accuracy

  22. Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose

  23. 15 years of GWAS discovery: Realizing the promise

  24. Genomics and phenomics of body mass index reveals a complex disease network

  25. Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study

  26. A saturated map of common genetic variants associated with human height

  27. Genetic footprints of assortative mating in the Japanese population

  28. Genetic and modifiable risk factors combine multiplicatively in common disease

  29. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

  30. Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

  31. Constrained human genes under scrutiny

  32. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

  33. Assortative mating biases marker-based heritability estimators

  34. Polygenic burden could explain high rates of affective disorders in a community with restricted founder population

  35. Discovery and implications of polygenicity of common diseases

  36. Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization

  37. Genomic partitioning of inbreeding depression in humans

  38. The trans-ancestral genomic architecture of glycemic traits

  39. Corrigendum to: Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness

  40. Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

  41. Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes

  42. Quantifying genetic heterogeneity between continental populations for human height and body mass index

  43. Widespread signatures of natural selection across human complex traits and functional genomic categories

  44. Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals

  45. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

  46. Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization

  47. Pathogenic variants in actionable MODY genes are associated with type 2 diabetes

  48. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

  49. Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

  50. Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock

  51. Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

  52. Risk in Relatives, Heritability, SNP-Based Heritability, and Genetic Correlations in Psychiatric Disorders: A Review

  53. A unified framework for association and prediction from vertex-wise grey-matter structure

  54. Alzheimer’s disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness

  55. No Evidence for Social Genetic Effects or Genetic Similarity Among Friends Beyond that Due to Population Stratification: A Reappraisal of Domingue et al (2018)

  56. Improved polygenic prediction by Bayesian multiple regression on summary statistics

  57. Genetic correlates of social stratification in Great Britain

  58. Extreme inbreeding in a European ancestry sample from the contemporary UK population

  59. Assortative Mating in Autism Spectrum Disorder: Toward an Evidence Base From DNA Data, but Not There Yet

  60. Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

  61. Genome-wide association study of medication-use and associated disease in the UK Biobank

  62. Imprint of assortative mating on the human genome

  63. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

  64. ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers

  65. Assortative mating on complex traits revisited: Double first cousins and the X-chromosome

  66. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

  67. Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

  68. Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

  69. Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

  70. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

  71. Misestimation of heritability and prediction accuracy of male-pattern baldness

  72. Association Between Population Density and Genetic Risk for Schizophrenia

  73. Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

  74. Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

  75. Signatures of negative selection in the genetic architecture of human complex traits

  76. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

  77. Reply to Kardos et al.: Estimation of inbreeding depression from SNP data

  78. Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

  79. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

  80. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

  81. Detection and quantification of inbreeding depression for complex traits from SNP data

  82. Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles

  83. Early metabolic markers identify potential targets for the prevention of type 2 diabetes

  84. An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

  85. Genome-wide physical activity interactions in adiposity – A meta-analysis of 200,452 adults

  86. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

  87. Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

  88. KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

  89. Genome-wide analysis identifies 12 loci influencing human reproductive behavior

  90. Detection of human adaptation during the past 2000 years

  91. Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling

  92. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

  93. Associations Between Type 2 Diabetes-Related Genetic Scores and Metabolic Traits, in Obese and Normal-Weight Youths

  94. Erratum: The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

  95. Genomic insights into the origin of farming in the ancient Near East

  96. The genetic architecture of type 2 diabetes

  97. Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis

  98. KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response

  99. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

  100. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

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